Annie and Baxter, the adult children of the controversial husband and wife conceptual performance art couple famous for their quirky macabre public performances, have never got over the fact that their parents kept using them during their childhood in their often gory and disturbing satirical public performances. They often clash with their now elderly parents over this and blame them for their problems in their adult life. However, the two become worried when they're told by the police that their parents have gone missing during their trip outside of town. The brother considers the possibility that something horrible might have happened to them, but the sister is convinced that it's just another one of their stupid games or twisted conceptual performances. She convinces him that they should go and look for them themselves.

A group of seven strangers try to survive and escape from isolated Los Angeles that has been infected by a strange, human changing virus.